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KMID : 1147120130190010021
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Journal of the Korean Society of Imaging Informatics in Medicine
2013 Volume.19 No. 1 p.21 ~ p.30
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Development and Evaluation of Virtual CT Imaging
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Yang Je-Pa
Jin Hyeong-Min
Kim Jong-Hyo
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Abstract
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This study proposes a virtual CT imaging method that can simulate the realistic CT images with a variety of factors acting on CT scans, which is integrated in computer software program. A fan-beam CT was used as the model. The energy spectrum depending on the X-ray tube voltage (KVp), quantum noise depending on the tube current (mAs), and the energy-dependent attenuation coefficient of the target material, etc. were modeled with reference to existing literature. And manufacturer- specific filters were simulated in the reconstruction process. In order to evaluate the performance of the developed virtual CT scan, a standard COPDgene phantom, which simulates the human chest, was imaged in an actual CT scanner (Sensation 16, SIEMENS) using eight different filter configurations and then images were synthesized under the same modeled conditions in the virtual CT. Images are compared to each other by visual similarity assessment for major structures, and by FWHM measurement calculation as a quantitative method. The virtual CT imaging method that was developed creates images that are visually very similar to the actual CT imaging using the various reconstruction filters, and figures measured with FWHM showed more than 95% agreement concurrence. The virtual CT imaging method developed in this study can be utilized as an efficient experimental tool in a variety of research for improved accuracy of quantitative imaging biomarker measurements in CT.
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KEYWORD
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Virtual CT, Image biomarker, lesion quantification, COPDgene phantom, CT reconstruction
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